Label-free target discovery technology of small molecule drug and its application in traditional Chinese medicines
10.16438/j.0513-4870.2022-1152
- VernacularTitle:非标记小分子药物靶点发现技术及其在中药研究中的应用
- Author:
Yuan-yuan LIN
;
Jin-hao YU
;
Hua-qiu LU
;
Xuan CHEN
;
Ning-bo CHEN
;
Jian-liang ZHOU
- Publication Type:Research Article
- Keywords:
rug target discovery technology;
label-free;
traditional Chinese medicine;
complex sample;
active component
- From:
Acta Pharmaceutica Sinica
2023;58(5):1117-1127
- CountryChina
- Language:Chinese
-
Abstract:
The discovery of drug targets plays a crucial role in drug research. Accurate information of small molecule drug-protein interaction can be provided by label-free target discovery technology without any structural modification at the small molecule. So, the label-free drug target discovery technology had become the powerful tool to discover the targets of drugs. Due to the “multi-component and multi-target” characteristics of traditional Chinese medicines (TCMs), the research on its targets and mechanism had been restricted. Based on potential of the label-free target discovery technology in the research of TCMs, this paper summarized the label-free target discovery technology and its application in TCMs research. It will provide a reference for the discovery of targets of TCMs and a new view for promoting the modernization of TCMs.
