Research progress of targeted degradation of Mycobacterium tuberculosis proteins
10.16438/j.0513-4870.2022-1119
- VernacularTitle:靶向降解结核分枝杆菌蛋白技术的研究进展
- Author:
Wei-jun XU
;
Li-fang YU
- Publication Type:Research Article
- Keywords:
italic>Mycobacterium tuberculosis;
rug resistance;
targeted protein degradation;
caseinolytic peptidase system;
BacPROTAC
- From:
Acta Pharmaceutica Sinica
2023;58(5):1221-1231
- CountryChina
- Language:Chinese
-
Abstract:
Tuberculosis (TB), an infectious disease caused by Mycobacterium tuberculosis (Mtb), is still one of the significant threats to human life. In recent years, the continuous exploration of small molecule inhibitors represented by bedaquinoline has brought new vitality into the field of tuberculosis. However, small molecule inhibitors will inevitably occur acquired drug resistance during clinical medication. As a new pharmacological mechanism, targeted protein degradation (TPD) achieves efficacy by destroying rather than inhibiting protein targets. It might be an excellent strategy to develop anti-tuberculosis drugs based on the TPD concept to solve drug resistance. This article reviews the protein degradation pathways of Mtb, such as the Pup proteasome system and the ClpP-ClpC1 complex enzyme system. The future development of these strategies into TPD drugs was prospected and summarized.
