Research on material basis and mechanism of traditional Chinese medicine based on intestinal metabolomics
10.16438/j.0513-4870.2022-1302
- VernacularTitle:基于肠道代谢组的中药药效物质基础和作用机制研究
- Author:
Shu-ting YU
1
,
2
;
Xue-mei QIN
3
;
Zhen-yu LI
3
Author Information
1. Institute of Taihang Materia Medica, Shanxi University of Chinese Medicine, Jinzhong 030619, China
2. Experimental Management Center, Shanxi University of Chinese Medicine, Jinzhong 030619, China
3. Modern Research Center for Traditional Chinese Medicine of Shanxi University, Taiyuan 030006, China
- Publication Type:Research Article
- Keywords:
Intestinal flora;
intestinal metabolite;
traditional Chinese medicine;
material basis;
research ideas
- From:
Acta Pharmaceutica Sinica
2023;57(7):1742-1750
- CountryChina
- Language:Chinese
-
Abstract:
The pharmacodynamic substance of traditional Chinese medicine (TCM) is an important basis for its mechanism and quality control, and also a key scientific issue for the inheritance and development of TCM. However, the complex characteristics of multi-component, multi-target and integrity of TCM, as well as the limitations of modern scientific research technical methods, have brought great challenges to the research. The interactions between Chinese medicine and intestinal flora provide us with a new idea. Based on the effective role of TCM and the hypothesis of correlation between intestinal flora and disease, the research on the material basis and mechanism of action of TCM based on intestinal metabolomics mostly explored the relationship between microflora and host phenotype, gradually deepening, and finally focused on the relationship between intestinal strains and molecular levels. This paper summarized the research ideas and key technologies of this model, in order to provide reference for the application of this model.
