Research on the mechanism of NLRP3 inflammasome in neurovascular unit impairment of diabetic retinopathy
10.3980/j.issn.1672-5123.2023.8.15
- VernacularTitle:NLRP3炎症小体在糖尿病视网膜病变神经血管单元损伤中的机制研究
- Author:
Qi ZHOU
1
,
2
;
Hong-Bin LYU
1
,
2
;
Ya-Ping WANG
1
,
2
;
Hao-Yue FENG
1
,
2
;
He-Jiang YE
1
,
2
Author Information
1. Chengdu University of Traditional Chinese Medicine, Chengdu 610072, Sichuan Province, China
2. Department of Ophthalmology, the Affiliated Hospital of Southwest Medical University, Luzhou 646000, Sichuan Province, China
- Publication Type:Journal Article
- Keywords:
diabetic retinopathy;
neurovascular unit;
inflammation;
nucleotide-binding oligomerization domain-like receptor protein 3(NLRP3)inflammasome
- From:
International Eye Science
2023;23(8):1317-1322
- CountryChina
- Language:Chinese
-
Abstract:
Diabetic retinopathy(DR)is a neurovascular disease caused by the neurovascular unit(NVU)impairment. Immune imbalance and inflammation are key factors that affect the normal function of NVU and lead to the progression of DR. Nucleotide-binding oligomerization domain-like receptor protein 3(NLRP3)inflammasome is indicated as an important component of the inflammatory response, and it can identify endogenous danger signals, leading to the activation of caspase-1 and then activating a series of inflammatory cytokines and pyroptosis. Early activation of inflammasome maintains and promotes innate immunity against bacterial and viral infections, while excessive inflammasome activation results in excessive expression and ongoing action of inflammatory proteins, which in turn triggers off immune disorders and an inflammatory cascade that seriously harms the body. This review summarizes the recent research progress on the mechanism of NLRP3 inflammasome in NVU impairment of DR, including the related drugs targeting NLRP3 pathways.
