The relationship between perioperative nausea and vomiting and serum serotonin concentrations in patients undergoing cesarean section under epidural anesthesia.
10.4097/kjae.2014.67.6.384
- Author:
Byung Gun LIM
1
;
Sang Sik CHOI
;
Yu Jin JEONG
;
Young Jin LIM
;
Yong Chul KIM
;
Kyoung Un PARK
;
Dong Kyu LEE
;
Mi Kyoung LEE
Author Information
1. Department of Anesthesiology and Pain Medicine, Guro Hospital, Korea University College of Medicine, Seoul, Korea. clonidine@empal.com
- Publication Type:Original Article
- Keywords:
Cesarean section;
Epidural anesthesia;
Perioperative nausea and vomiting;
Serum serotonin
- MeSH:
Anesthesia, Epidural*;
Cesarean Section*;
Constriction;
Female;
Humans;
Nausea*;
Pilot Projects;
Pregnancy;
Receptors, Serotonin, 5-HT3;
Serotonin*;
Umbilical Cord;
Vomiting*
- From:Korean Journal of Anesthesiology
2014;67(6):384-390
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Serotonin-also known as 5-hydroxytryptamine or 5-HT-can induce nausea and vomiting (NV) by peripheral mechanisms via the activation of 5-HT3 receptors. In this study, we observed perioperative NV, including intraoperative NV, and changes in serum 5-HT concentrations. We evaluated the relationship between perioperative NV and serum 5-HT levels in patients undergoing cesarean section under epidural anesthesia, and carried out a pilot study to determine if further studies on a larger scale were justified. METHODS: Twenty-eight patients who were scheduled for cesarean section under epidural anesthesia were included in the study. Patients were assigned to 2 groups according to the occurrence of NV after induction, i.e., an NV-positive or an NV-negative group. Serum 5-HT concentrations were measured before induction, at the time that NV occurred (in the case of the NV-positive group) or 5 min after the umbilical cord clamping (in the case of the NV-negative group) during surgery, and at 2 h postoperatively. RESULTS: NV occurred in 10 of the 28 patients. No significant differences in serum 5-HT concentrations were found within or between the two groups. CONCLUSIONS: This study suggests that there is no correlation between serum 5-HT concentration and the occurrence of perioperative NV in patients undergoing cesarean section under epidural anesthesia, and the findings do not seem to support further investigations regarding a possible relationship between serum 5-HT concentration and perioperative NV.
