Experimental study of bone and cartilage transplantation to repair the defect of articular cartilage
- VernacularTitle:骨软骨镶嵌移植修复关节软骨缺损的实验研究
- Author:
Haichao DONG
;
Jingnian LI
;
Feng NAN
- Publication Type:Journal Article
- Keywords:
knee joint, cartilage defect, transplantation
- From:
Chinese Journal of Rehabilitation Theory and Practice
2005;11(10):816-819
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo explore the effect and feasibility of autograft and allograft bone and cartilage transplantation.Methods63 rabbits were made experimental defect in the same side knee joint,and were divided randomly into group A(autograft group),group B(allograft group) and group C(control group).Group A was divided further into 2 column limiting motion subgroup(A2M group),not limiting motion subgroup(A2N group) and 4 column subgroup(A4M group).In the same way,group B was divided further into B2M group,B2N group and B4M group.Every subgroup included nine rabbits,and the transplantation was made in no weight-bear area of knee joint.The generally observation were made,the joint movable range and the thickness of the repairing tissue were measured,histology change of transplanted tissue(through light,electronic microscope)were observed.ResultsGroup A had a satisfactory result,and the result of no limiting groups were better.The result of A4M group was better than A2M group (P≤0.05).The result of group B was not good.ConclusionThe bone-cartilage column of small diameter and general number are beneficial in repairing the defect of joint cartilage.The allograft bone and cartilage transplantation can cause seriously immunoreaction and the absorption of cartilage pole,and is detrimental to repair the defect of joint cartilage.
