Effect of Shenmai Injection on neuroendocrine factors and cytokines in patients with chronic heart failure
- VernacularTitle:参麦注射液对慢性心力衰竭患者的神经内分泌和细胞因子的影响
- Author:
Wenzhi HU
;
Lie SUN
;
Jiming YANG
;
Mei HONG
;
Zhenzhong JIANG
;
Boqing ZHANG
;
Haibo ZHOU
- Publication Type:Journal Article
- Keywords:
chronic heart failure, Shenmai Injection, neurohumoral activity, cytokines
- From:
Chinese Journal of Rehabilitation Theory and Practice
2005;11(9):742-743
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the effects of Shenmai Injection(SI) on chronic systolic heart failure patients.Methods120 chronic heart failure patients were randomly divided into routine treatment and the routine treatment and SI group. The changes of angiotension Ⅱ(Ang Ⅱ), aldosterone(Ald), endothelin-1 (ET-1), interleukin-6 (IL-6), tumour necrosis factor-α (TNF-α), plasm rennin activity (PRA), cardionatrin(ANP), brain natriuretic peptide (BNP), cardiac function were observed.ResultsAfter treatment, LVEF,stage of NYHA increased in two groups,LVDs, LVDd and the level of Ang Ⅱ,Ald, ET-1, IL-6, TNF-α,PRA, ANP and BNP decreased in both groups(P<0.05). LVEF, stage of NYHA in the routine treatment and SI group incresed more significantly than those in routine treatment group(P<0.05). LVEDs, LVEDd and the level of Ang Ⅱ,Ald, ET-1, IL-6, TNF-α,PRA, ANP and BNP in the routine treatment and SI group were decreased more significantly than those in routine treatment group (P<0.05).ConclusionSI can improve not only the disturbed endocrine function and cytokines, but also left ventricular function.
