Effects of electro-acupuncture on behavioral recovery and its molecular basis in chronic spinal cord injured rats
- VernacularTitle:电针治疗大鼠慢性脊髓损伤疗效观察及分子机制的实验研究
- Author:
Xinjia WANG
;
Kangmei KONG
;
Weilian YE
;
Weili QI
;
Peisong SONG
;
Yanling CAI
- Publication Type:Journal Article
- Keywords:
spinal cord injury, electro-acupuncture, neurotrophin-3, behavior, rat
- From:
Chinese Journal of Rehabilitation Theory and Practice
2005;11(9):716-718
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo study the therapeutic mechanisms of electro-acupuncture on chronic spinal cord injury in rats.MethodsA model of chronic spinal cord injury was made. After 60 days, the pressure installs were removed, and the animals were treated with electro-acupuncture. A quantitive analysis was carried out using Basso, Beattie, Bresnahan Locomotor Rating Scale (BBB scale). The expression of Neurotrophin-3 (NT-3) and its receptor TrkC were observed through immunohistochemistrical method and western blotting.ResultsAfter spinal cord injury, enhanced NT-3 and TrkC immunoreactivities were evident in neurons and glial cells. Furthermore, they were diminished in the electro-acupuncture group. Meanwhile, both evoked potentials and BBB scales were improved after EA treatment (P<0.05). ConclusionThe treatment of electro-acupuncture may promote behavioral function recovery of experimental animals, and NT-3 and TrkC may take part in the recovery.
