Potential value of mesenchymal stem cells and their derivatives in repairing donor liver
10.3969/j.issn.1674-7445.2023.04.017
- VernacularTitle:间充质干细胞及其衍生物对供肝修复的潜在价值
- Author:
Yiting WANG
1
;
Jie JIANG
;
Li MA
;
Zongqiang HU
;
Li LI
Author Information
1. Postdoctoral Workstation of Ganmei Hospital Affiliated to Kunming Medical University, Kunming 650000, China
- Publication Type:Research Article
- Keywords:
Mesenchymal stem cell;
Exosome;
Extracellular vesicle;
Liver transplantation;
Marginal donor liver;
Steatosis;
Liver regeneration;
Ischemia-reperfusion injury
- From:
Organ Transplantation
2023;14(4):592-
- CountryChina
- Language:Chinese
-
Abstract:
In recent years, organ transplantation has developed rapidly in China, whereas the proportion of supply and demand of organs for donation is severely unbalanced. To resolve the shortage of donor livers, repairing extended criteria donor liver and improving the quality of donor liver are critical research directions. Mesenchymal stem cell (MSC) is a category of stem cells with self-renewal and differentiation potential, which possess the functions of immunomodulation and tissue repair. The derivatives of MSC have the advantages of low immunogenicity and high biocompatibility, which have been widely applied in the treatment of multiple diseases. In this article, research progress on the role of MSC, exosomes and extracellular vesicles in alleviating liver steatosis, repairing ischemia-reperfusion injury and promoting the regeneration of small-for-size liver allograft was reviewed, and the feasibility and safety of MSC and the derivatives in repairing donor liver were summarized, aiming provide novel ideas for repairing marginal donor liver and enhancing the quality of liver allograft.
