Application progress on contrast-enhanced ultrasound in acute rejection after kidney transplantation
10.3969/j.issn.1674-7445.2023.04.007
- VernacularTitle:超声造影技术在肾移植术后急性排斥反应中的应用进展
- Author:
Qianghua LENG
1
;
Fei HAN
;
Zhengyu HUANG
Author Information
1. Department of Kidney Transplantation, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China
- Publication Type:Research Article
- Keywords:
Kidney transplantation;
Acute rejection;
Contrast-enhanced ultrasound;
Ultrasound microbubble;
Inflammatory cell infiltration;
Small interfering RNA;
T cell-mediated rejection;
Renal parenchymal injury
- From:
Organ Transplantation
2023;14(4):514-
- CountryChina
- Language:Chinese
-
Abstract:
Early diagnosis of acute rejection is of significance for the protection of renal allograft function. Pathological puncture biopsy is the gold standard for the diagnosis of acute rejection of renal allografts. Nevertheless, it may provoke multiple complications, such as bleeding, infection and renal parenchymal injury, which limit its widespread application. In recent years, the sensitivity of contrast-enhanced ultrasound in the diagnosis of acute rejection has been constantly improved. Ultrasound-targeted microbubble technique has further enhanced the diagnostic specificity of contrast-enhanced ultrasound, making it possible to replace pathological puncture biopsy. Besides, in the field of acute rejection treatment, microbubble ultrasonic cavitation may promote local delivery of immunosuppressants by inducing sonoporation and exhibit anti-rejection effect. In this article, the application of contrast-enhanced ultrasound in the diagnosis and treatment of acute rejection after kidney transplantation was reviewed, aiming to provide reference for widespread application of contrast-enhanced ultrasound in kidney transplantation.
