Secondary metabolites of endophytic fungus Aspergillus sp. J218 from Anectochilus roxburhii
10.12206/j.issn.2097-2024.202208068
- VernacularTitle:金线莲内生真菌Aspergillus sp. J218的次生代谢产物研究
- Author:
Xuhui HE
1
;
Xiang-ang LI
1
;
Meiyan CHEN
1
;
Yiding WANG
1
;
Rui WU
1
;
Chengjian ZHENG
1
Author Information
1. School of Pharmacy, Naval Medical University, Shanghai 200433，China.
- Keywords:
Aspergillus sp. J218;
Anectochilus roxburhii;
endophytic fungi;
secondary metabolites;
dimeric naphthopyrones
- From:
Journal of Pharmaceutical Practice
2023;41(7):411-415
- CountryChina
- Language:Chinese
-
Abstract:
Objective To isolate the secondary metabolites of endophytic fungus Aspergillus sp. J218 from Anectochilus roxburhii. Methods Different chromatographic methods, including Sephadex LH-20 and silica gel chromatography as well as HPLC, were used to isolate compounds from the EtOAc fraction of the solid fermentation of J218, and their structures were identified by spectral methods. Results Ten compounds were isolated from the fermentation of J218 and their structures were individually identified as kotanin（1）, flavasperone（2）, aurasperone B（3）, fonsecinone B（4）, fonsecinone D（5）, ensidol A（6）, fonsecinone A（7）, fonsecinone C（8）, aurasperone A（9）, and fonsecinone F（10）. Conclusion Most compounds isolated from endophytic fungus Aspergillus sp. J218 in Anectochilus roxburhii were identified as dimeric naphthopyrones. These results suggest that this strain contains rich dimerization synthase, which could provide clues for the further exploration of the rational biosynthesis pathway of dimeric naphthopyrones in this strain.
