Relationship Between NLRP3 Inflammasome and Diabetic Cardiomyopathy and Intervention Effect of Traditional Chinese Medicine： A Review
10.13422/j.cnki.syfjx.20230715
- VernacularTitle:NLRP3炎症小体与糖尿病心肌病的关系及中医药调控研究进展
- Author:
Sai ZHANG
1
;
Zhengtao CHEN
1
;
Shiyun TANG
1
;
Chunguang XIE
1
;
Lian DU
1
;
Hong GAO
1
Author Information
1. Hospital of Chengdu University of Traditional Chinese Medicine（TCM）， Chengdu 610075， China
- Publication Type:Journal Article
- Keywords:
NOD-like receptor protein 3 （NLRP3） inflammasome;
diabetic cardiomyopathy;
traditional Chinese medicine
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2023;29(16):250-263
- CountryChina
- Language:Chinese
-
Abstract:
Diabetic cardiomyopathy （DCM） is one of the complications of diabetes. It refers to a specific type of idiopathic cardiomyopathy that occurs in individuals with diabetes， distinct from other cardiovascular diseases such as coronary heart disease， valvular heart disease， or congenital heart disease. It has also been identified as one of the leading causes of death in diabetic patients for many years. Research has shown that the pathogenesis of DCM is closely associated with insulin resistance， activation of various inflammatory responses， increased oxidative stress， impaired coronary microcirculation， and accumulation of advanced glycation end products （AGEs）. Among various inflammatory responses， the activation of the NOD-like receptor protein 3 （NLRP3） inflammasome can induce the secretion of a large amount of pro-inflammatory cytokines through the cascade reaction of inflammation， subsequently mediating cellular pyroptosis and promoting myocardial damage. Currently， extensive experimental studies on traditional Chinese medicine （TCM） have been conducted in China and abroad based on the significant role of the NLRP3 inflammasome in the prevention and treatment of DCM. These studies have demonstrated that Chinese medicinal extracts， such as Astragalus polysaccharide and ginsenoside Rb1， single drugs like Coriolus and Cordyceps， and Chinese medicinal formulas like Didangtang and modified Taohe Chengqitang， as well as acupuncture and TCM exercise therapy， can regulate the relevant pathways of the NLRP3 inflammasome to inhibit its assembly or activation， reduce inflammatory responses， inhibit myocardial remodeling in DCM， and improve cardiac function. This article reviewed the relationship between the NLRP3 inflammasome and DCM， as well as the research progress on TCM in exerting anti-inflammatory effects in this field， aiming to provide new insights for the development of therapeutic approaches for DCM.
