Progress of Rhei Radix et Rhizoma and Its Combination in Treatment of Cerebral Hemorrhage： A Review
10.13422/j.cnki.syfjx.20230738
- VernacularTitle:大黄及其组方配伍治疗脑出血研究进展
- Author:
Dahe QI
1
;
Hua MA
2
;
Yuanyuan CHEN
1
;
Kexin WANG
1
;
Mengmeng DING
1
;
Yunlong HAO
1
;
Ye GUO
1
;
Lingbo KONG
1
Author Information
1. Dongzhimen Hospital， Beijing University of Chinese Medicine， Beijing 100700， China
2. Affiliated Hospital of Nanjing University of Chinese Medicine， Nanjing 210029， China
- Publication Type:Journal Article
- Keywords:
Rhei Radix et Rhizoma;
formula;
active ingredients;
cerebral hemorrhage;
clinical research;
basic experiment
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2023;29(16):237-249
- CountryChina
- Language:Chinese
-
Abstract:
Cerebral hemorrhage accounts for about 10%-15% of all strokes， and its pathogenesis is complex. Currently， the main clinical treatment is mainly medical symptomatic treatment， including the use of antihypertensive drugs， hypoglycemic drugs， and hemostatic drugs， and surgical treatment is required in some cases， but there is still a lack of effective treatment. In recent years， traditional Chinese medicine and proprietary Chinese medicine have been widely accepted for their stable efficacy， high safety， and low cost. Rhei Radix et Rhizoma is one of the most commonly used herbal medicines for the treatment of cerebral hemorrhage. This paper summarizes the relevant literature on the treatment of cerebral hemorrhage with Rhei Radix et Rhizoma and finds that its active ingredients are mainly anthraquinones， such as emodin， Rhei Radix et Rhizoma acid， and Rhei Radix et Rhizoma phenol. The herbal formulas are Da Chengqitang， Shengdi Dahuangtang， Liangxue Tongyufang， and Naoxueshu oral liquid. The effects involve protecting the blood-brain barrier， promoting hematoma absorption， reducing inflammation levels， decreasing lactic acid accumulation at the bleeding site， and increasing the expression of brain-derived neurotrophic factors. The pathways involved include aquaporin 4 （AQP4）， phosphatidylinositol 3-kinase/protein kinase B （PI3K/Akt）， extracellular signal-regulated kinase 1/2 （ERK1/2）， Toll-like receptor 4 （TLR4）， nuclear transcription factor-κB （NF-κB）， nuclear factor E2-related factor 2 （Nrf2）， and Wnt3a/β-linked protein pathway. This paper summarizes the progress of clinical studies and animal experiments on the treatment of cerebral hemorrhage with active ingredients of Rhei Radix et Rhizoma and herbal compounds containing Rhei Radix et Rhizoma， so as to provide a reference for the treatment protocol of cerebral hemorrhage.
