Effect of Anmeidan on Serum Levels of BDNF， GFAP， and Irisin in Patients with Chronic Insomnia
10.13422/j.cnki.syfjx.20230291
- VernacularTitle:安寐丹对慢性失眠患者血清BDNF、GFAP和Irisin的影响
- Author:
Jie YAGNG
1
;
Yunxia TAN
1
;
Ping WANG
1
;
Ling LIU
1
;
Li LI
2
;
Ke JI
2
;
Fugui LIU
1
;
Huanhuan DONG
2
;
Fuping XU
3
;
Yujun LU
4
;
Yanbo FAN
5
Author Information
1. Hubei University of Chinese Medicine，Wuhan 430065，China
2. Hubei Provincial Hospital of Traditional Chinese Medicine（TCM），Affiliated Hospital of Hubei University of TCM；Hubei Academy of TCM，Wuhan 430061，China
3. Guangdong Provincial Hospital of TCM，Guangzhou 510120，China
4. Affiliated Hospital of Gansu University of Chinese Medicine，Lanzhou 730000，China
5. Wuhan Hospital of TCM，Wuhan 430010，China
- Publication Type:Journal Article
- Keywords:
Anmeidan;
chronic insomnia;
serum glial fibrillary acidic protein;
brain-derived neurotrophic factor;
irisin
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2023;29(16):170-177
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo explore the effect of Anmeidan on the sleep quality and serum levels of brain-derived neurotrophic factor （BDNF）， glial fibrillary acidic protein （GFAP）， and irisin in the patients with chronic insomnia. MethodA multicenter， randomized， double-blind， placebo-controlled clinical study was carried out， including 480 patients with chronic insomnia （deficiency syndrome） in Wuhan （Hubei）， Guangzhou （Guangdong）， and Lanzhou （Gansu）. They were randomized into an observation group and a control group at a ratio of 1∶1. The observation group was orally administered with Anmeidan granules at a dose of 11 g， 3 times per day， and the control group with Anmeidan simulant at a dose of 11 g， 3 times per day， Both groups of patients received sleep education after enrollment. After 4 weeks of medication， the Athens insomnia scale （AIS） scores， Spiegel scale scores， and serum levels of BDNF， GFAP， and irisin were compared between the two groups as well as between before and after treatment. ResultA total of 480 adult patients with chronic insomnia were enrolled in this study， with 64 patients falled off. Finally， the 415 patients were included in the analysis， including 213 patients in the observation group and 202 patients in the control group. There was no difference in age or sex between the two groups of patients. Compared with before treatment， the treatment in both groups decreased the AIS and Spiegel scores （P<0.01）. After treatment， the observation group had lower AIS and Spiegel scores than the control group （P<0.01）. The treatment in the observation group slightly lowered the level of BDNF， elevated the level of irisin （P<0.05）， and lowered the level of GFAP （P<0.05） in the serum. After treatment， the observation group showed higher level of irisin （P<0.05） and lower levels of BDNF and GFAP in the serum than the control group. ConclusionAnmeidan may improve the sleep quality of patients with chronic insomnia by elevating the irisin level and lowering the GFAP level in the serum.
