Effect of alanyl-glutamine on immune function of patients with gastric cancer
- VernacularTitle:丙氨酰谷氨酰胺双肽对胃癌患者术后免疫功能的影响
- Author:
Jianyong ZHENG
;
Weizhong WANG
;
Wenxian GUAN
;
Dongli CHEN
;
CHongduang ZHANG
- Publication Type:Journal Article
- Keywords:
parenteral nutrition, alanyl-glutamine, gastric cancer, immune function
- From:
Chinese Journal of Rehabilitation Theory and Practice
2005;11(8):656-657
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the effect of alanyl-glutamine supplemented total parenteral nutrition (TPN) on immune function of patients with gastric cancer.MethodsFifty gastric cancer patients with radical gastrectomy were randomly divided into the control group (n=25) and experiment group (n=25). Patients in the control group received conventional TPN support, and patients in the experiment group received TPN support and alanyl-glutamine (0.34 g/kg). All patients were observed for 7 days. The levels of IgG, IgA, IgM, CD3, CD4, CD8 and CD4/CD8 were measured before operation and on first and eighth day after operation.ResultsAll the levels of immune function were decreased on first day after operation in two groups. But the levels of IgG, IgA, IgM, CD3, CD4 and CD4/CD8 were significantly different between two groups on eighth day after operation (P<0.05). No serious infectious complication occurred in both groups.ConclusionTPN supplemented with alanyl-glutamine can improve the immune function of patients with gastric cancer radical gastrectomy.
