Quantification of Muscle Metabolites Using Proton Magnetic Resonance Spectroscopy (1 H-MRS) for Incomplete Spinal Cord Injury Patients: Preliminary Study
- Author:
Nur Syahfinaz Hidayah Rusli
1
;
Faikah Zakaria
1
;
Hairil Rashmizal Abdul Razak
2
Author Information
- Publication Type:Journal Article
- Keywords: 1 H-MRS, Muscle metabolites, CHO, Cr, IMCL, FES
- From:Malaysian Journal of Medicine and Health Sciences 2021;17(No.2):4-10
- CountryMalaysia
- Language:English
- Abstract: Introduction: This preliminary study aimed to non-invasively evaluate choline (CHO), creatine (Cr) and intramyocellular lipid (IMCL) metabolites in skeletal muscles at pre- and post-functional electrical stimulation (FES) exercise among incomplete spinal cord injury (SCI) of American Spinal Injury Association Impairment Scale (ASIA-AIS) D patients using proton magnetic resonance spectroscopy or 1 H-MRS. Methods: These metabolites were measured from the vastus lateralis and semitendinosus muscles of three incomplete SCI ASIA-AIS D patients who completed the FES exercise and later underwent 3 Tesla (T) MRI (repetition time/echo time; TR/TE of 3500ms/100ms, field-ofview; FOV of 20cm, slice thickness of 6mm) and 1 H-MRS (TR/TE of 2000ms/31ms, voxel size of 20mm x 20mm x 35mm). Results: Out of those selected metabolites, only CHO value of vastus lateralis showed a statistically significant difference between pre- and post FES exercise 1 H-MRS scanning (p = 0.01). Conclusion: Therefore, this preliminary finding has postulated that the quantification of muscle metabolites using 1 H-MRS imaging could be used as a potential indicator in evaluating the muscle strength for incomplete SCI ASIA-AIS D patients after the completion of FES cycling exercise.
- Full text:11.2021my1012.pdf
