Novel use of GnRH agonist as neoadjuvant treatment for giant endometrial polyps

Author: Diana J. Cupino-Arcinue ¹ ; Regina Paz Tan-Espiritu ¹
Author Information

1. Section of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Philippine General Hospital, University of the Philippines Manila
Publication Type:Journal Article
Keywords: Giant endometrial polyp; GnRH agonist; hysteroscopic removal
MeSH: Neoadjuvant Therapy; Polyps
From: Philippine Journal of Reproductive Endocrinology and Infertility 2018;15(2):29-36
CountryPhilippines
Language:English
Abstract: Endometrial polyp, being one of the most common causes of abnormal uterine bleeding, is formed from localized overgrowths of endometrial tissue brought about by increased estrogen levels. Sizes of polyps usually are less than 2cm, while those >4 cm are labeled as giant polyps. Such polyps can even occupy the entire endometrial cavity, making complete hysteroscopic removal difficult and prone to failure and morbidity. Limited literature regarding use of GnRH agonist in endometrial polyps are published, but given the idea that it induces a state of hypoestrogenism, it could be a promising approach for neoadjuvant treatment in such cases. In this paper, 3 cases of giant endometrial polyps with fertility problems were given GnRH agonists prior to resection. All cases have shown significant decrease in size of their polyps, making complete and successful hysteroscopic removal feasible.
Full text:PJREI 5.pdf