Effects of nerve growth factor on the nerve function and nitric oxide synthase to acute cerebral embolism in rats
- VernacularTitle:神经生长因子对急性脑梗死大鼠神经功能和一氧化氮合酶含量的影响
- Author:
Yiguang WANG
;
Zhijian LI
;
Yuliang WANG
;
Kexin TANG
- Publication Type:Journal Article
- Keywords:
acute cerebral infarction, nerve growth factor (NGF), neurological grades, nitric oxide synthase (NOS), rats
- From:
Chinese Journal of Rehabilitation Theory and Practice
2005;11(8):597-598
- CountryChina
- Language:Chamorro
-
Abstract:
ObjectiveTo observe the curative effects of nerve growth factor (NGF) on experimental acute cerebral thromboemblia rats and study the mechanisms preliminarily.Methods24 model rats were randomly divided into three groups treated respectively with NGF, citicoline sodium (CS) and normal saline (NS) for 20 days, and the neurological grades of animals were observed before and after treatment. Then, 55 rats were randomly divided into three groups: the treated group (25 model rats, treated with NGF), control group (25 model rats, treated with NS) and normal group (5 normal rats, without treatment), the levels of nitric oxide synthase (NOS) of all animals were measured at 1 h, 3 h, 6 h, 12 h and 24 h after acute cerebral thromboemblia established.ResultsThe neurological grades of both NGF and CS treated groups were significantly lowered after treatment compared with NS control group ( P<0.05). NOS levels of cerebral thromboemblia areas were higher than that in the control group 1 hour, 3 hours after acute cerebral thromboemblia, the levels of NOS in NGF treatment group were obviously lower than that in the control group post-traumatic 1 hour, 3 hours and 6 hours.ConclusionNGF can accelerate the nervous function recovery of the rat with acute cerebral thromboemblia, the mechanisms is that NGF prohibits neurotoxicity of NOS.
