Effect of Yuxingchangzhi Decoction on level of norepinephrine and 5-hydroxyptamin in serum of patients with post-stroke depression
- VernacularTitle:郁星菖志汤对急性脑卒中后抑郁症患者血清去甲肾上腺素和5-羟色胺的影响
- Author:
Jie-fei HONG
;
Jun-liang LI
- Publication Type:Journal Article
- Keywords:
post-stroke depression, Yuxingchangzhi Decoction, norepinephrine, 5-hydroxyptamin
- From:
Chinese Journal of Rehabilitation Theory and Practice
2004;10(5):297-298
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo evaluate the effect of Yuxingchangzhi Decoction on level of norepinephrine (NE) and 5-hydroxyptamin (5-HT) in serum of patients with post-stroke depression. Methods76 patients with post-stroke depression were treated with Yuxingchangzhi Decoction or placebo for 4 weeks. Before and after treatment, all the patients were evaluated with the Hamilton Rating Scale for Depression (HAMD),while the level of NE and 5-HT in serum of patients were measured.ResultsThe total score of HAMD of the patients of Yuxingchangzhi Decoction group was significantly different before and after treatment (P<0.01),while that of the placebo group was not significantly different (P>0.05). The NE and 5-HT level in serum of patients of the Yuxingchangzhi Decoction group were significantly different before and after treatment (P<0.01),but that of the placebo group was not significantly different (P>0.05). ConclusionYuxingchangzhi decoction can raise NE,5-HT level in patients with post-stroke depression and alleviate symptoms of depression significantly.
