Effect of nitric oxide on expression of CD44 of osteosarcoma cell line
- VernacularTitle:一氧化氮对骨肉瘤细胞表面CD44表达的影响
- Author:
Xinyu ZHANG
;
Zhengda KUANG
;
Chuanyi YANG
- Publication Type:Journal Article
- Keywords:
nitric oxide, Osteosarcoma, sodium nitroprusside, CD44
- From:
Chinese Journal of Rehabilitation Theory and Practice
2005;11(7):552-552
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo study the influence of nitric oxide on the expression of CD44 of human osteosarcoma cell line (HOS).MethodsDifferent concentrations of sodium nitroprusside (SNP) were added into the culture solution of HOS in vitro. Through immunohistochemistry method (SP), the expression of CD44 were observed.ResultsThe expression of CD44 was depressed when the concentration of SNP was increased. ConclusionNitric oxide can depress the expression of CD44 of HOS and maybe change the invasive or metastatic abilities of HOS.
