Study of effect of clenbuterol,a β2-adrenoceptor agonist on the recovery of locomotor function following spinal cord injury in rats
- VernacularTitle:Clenbuterol对大鼠脊髓损伤后运动功能恢复作用研究
- Author:
Yan ZHANG
;
Yiying LI
;
Jizong ZHAO
;
Shuo WANG
;
Xiangming LIU
- Publication Type:Journal Article
- Keywords:
clenbuterol, spinal cord injury, locomotor function
- From:
Chinese Journal of Rehabilitation Theory and Practice
2005;11(7):546-547
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo determine whether the β2-agonist, clenbuterol, can improve recovery of locomotor function following spinal cord injury.MethodsThe spinal cords of rats were contused with a weight-drop apparatus similar to the NYU impactor at the lever of T10. Locomotor function was determined with the Basso, Beattie, Bresnahan (BBB) Scale. Following 6 weeks of behavioral evaluation, the spinal cords were received histological examination.ResultsClenbuterol improved the recovery of locomotor function and increased the amount of spared spinal cord tissue.ConclusionClenbuterol caused the enhancement of recovery of locomotor function and spared spinal cord tissue following contusion.
