Value of cerebrovascular hemodynamic indexes in the dosing of nimodipine followed subarachnoid hemorrhage
- VernacularTitle:尼莫地平治疗蛛网膜下腔出血脑循环动力学参数的研究
- Author:
Hui WANG
;
Guifang CAO
;
Wen HE
;
Jinghong ZHANG
;
Yilu XIA
;
Yang SHEN
- Publication Type:Journal Article
- Keywords:
nimodipine, subarachnoid hemorrhage, cerebrovascular hemodynamics
- From:
Chinese Journal of Rehabilitation Theory and Practice
2005;11(7):540-542
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo to evaluate the effects of nimodipine on cerebrovascular function in subarachnoid hemorrhage(SAH) using cerebrovascular hemodynamic indexes (CVAI),and to study the clinical value of CVAI in the dosing of nimodipine after SAH.Methods58 patients with SAH were given nimodipine 0.25 μg/kg·min by intravenous drip(i.v) after admitted to hospital. CVAI and NIHSS were examind before and 1 d, 7 d, 14 d after intravenous. ResultsNimodipine improved cerebrovascular function significantly, including increasing cerebral blood velocity and flow, decreasing cerebrovascular resistance(R) and critical pressure(CP). For those patients with NIHSS worse and R value increased, increased dosing could decrease cerebrovascular resistance(P<0.05) and improve neurological function significantly(P<0.05). ConclusionIndividualization is necessary in dosing of nimodipine treatment of SAH. R value is a important index in adjusting the dose of nimodipine.
