Effect of topiramate on Heat Shock Protein 70 expression after cerebral ischemia and reperfusion injury
- VernacularTitle:托吡酯促进高血压鼠脑缺血再灌注损伤后热休克蛋白70表达的研究
- Author:
Shengliang SHI
;
Guinan BI
;
Jianping JIA
;
Zhuchang JIANG
- Publication Type:Journal Article
- Keywords:
topiramate, cerebral ischemia, reperfusion, Heat Shock Protein 70
- From:
Chinese Journal of Rehabilitation Theory and Practice
2005;11(7):512-513
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo study the effect of topiramate on the expression of Heat Shock Protein 70 (HSP70) after brain ischemia and reperfusion injury.MethodsWistar rats were performed operation of double renal artery stenosis to make hypertension. 2 months after, the rats were separated into 3 groups randomly: topiramate group,ischemic reperfusion group and fake operation control group. The rats were performed operation of middle cerebral artery occlusion (MCAO) and made them in ischemia for 2 h. One day later, their brains were obtained, and the number of positive and negtive cells were counted by computerized pathological image analyzer.ResultsThe HSP70 expression of topiramate group was higher than that of ischemic reperfusion group(P<0.05).No positive cell had been found in the samples of the control group.ConclusionTopiramate can enhance the expression of HSP70 and may therefore protect the ischemic brain tissue from reperfusion injury.
