Loss of heterozygosity of microsatellite DNA on 6q in bladder tumor
- VernacularTitle:膀胱肿瘤6号染色体长臂的杂合性缺失研究
- Author:
Fan CHENG
;
Yong-lie CHU
;
Da-lin HE
;
Lin YANG
;
Ping CHEN
;
E YANG
;
Xiang LIU
- Publication Type:Journal Article
- Keywords:
bladder tumor, loss of heterozygosity (LOH), long arm of chromosome 6(6q)
- From:
Chinese Journal of Rehabilitation Theory and Practice
2004;10(5):279-280
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the loss of heterozygosity (LOH) on 6q in bladder tumor.MethodsD6S404 and D6434 microsatellite markers near 6q21 were tested by PCR-SSLP-stain method on tumor DNA from 31 cases of bladder tumor.ResultsAmong these 31 cases of bladder tumor,LOH was detected in tumor tissues on site for D6S404 (35.5%) and D6S434(22.6%).ConclusionOne or more tumor suppressor gene near 6q21 maybe relevant for the development of bladder tumor.
