Anti-N-methyl-D-aspartate receptor (NMDAR) Encephalitis in  Malaysia: A Review Article

Su Tein Sim; Peck Kee Chia; Keng Hong Chhoa; Bin Shen Chai

Return

Anti-N-methyl-D-aspartate receptor (NMDAR) Encephalitis in Malaysia: A Review Article

Author: Su Tein Sim ¹ ; Peck Kee Chia ² ; Keng Hong Chhoa ³ ; Bin Shen Chai ⁴
Author Information

1. A.H Lee Specialist Clinic, 38-1, Jalan 52/4, Bandar Baru Petaling Jaya, 46200 Petaling Jaya, Selangor, Malaysia
2. Department of Neurology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia
3. Department of Psychiatry, Hospital Kuala Lumpur, Jalan Pahang, 50586 Kuala Lumpur, Wilayah Persekutuan Kuala Lumpur
4. Department of Obstetric and Gynaecology, Hospital Sungai Buloh, Jalan Hospital, 47000 Sungai Buloh, Selangor, Malaysia
Publication Type:Review
Keywords: Anti-NMDAR encephalitis, NMDAR antibody, Autoimmune, Encephalitis, Malaysia
From:Malaysian Journal of Medicine and Health Sciences 2021;17(No.1):163-169
CountryMalaysia
Language:English
Abstract: N-methyl-D-aspartate receptor (NMDAR) antibody encephalitis is recognized as an autoimmune encephalitis, which is due to autoantibodies against synaptic NMDAR. This disorder affects individuals aged 23 months to 76 years and has a wide range of presentations. In Malaysia, more than 20 cases have been reported. Timely diagnosis and definitive immunotherapy are vital in optimizing functional recovery and prognosis. However, early diagnosis of the condition is often missed due to low awareness among clinicians in Malaysia. This article gathered the medical literature from Malaysia and highlights the aetio-pathophysiology, clinical presentation and management of the disease.
Full text:11.2021my1004.pdf