Childhood bullous pemphigoid: A case report
- Author:
Gemma Theresa C. David-Corpuz
1
;
Cathrine B. Ang
1
;
Camille B. Angeles
1
;
Maria Jasmin J. Jamora
1
,
2
;
Lian C. Lian C. Jamisola
1
Author Information
- Publication Type:Case Reports
- Keywords: Immunodermatology; Pediatric dermatology
- MeSH: Pemphigoid, Bullous
- From: Journal of the Philippine Dermatological Society 2022;31(2):44-47
- CountryPhilippines
- Language:English
-
Abstract:
Introduction:Bullous pemphigoid (BP) is an acquired autoimmune subepidermal bullous disease characterized by linear depo-
sition of IgG and C3 along the basement membrane. It rarely occurs in childhood, especially in adolescence, with only 14 cases
identified in literature. Treatment of choice is systemic corticosteroids but other treatment options such as anti-inflammatory
antibacterials and methotrexate are available.
Case report:A 16-year-old Filipino girl presented with a three-month history of generalized vesicles and bullae. Nikolsky and Asboe-Hansen signs were negative. Histopathology and direct immunofluorescence were consistent with BP. ELISA to BP180 au- toantibody levels was elevated at 135 IU (normal <9 IU). Complete blood count showed leukocytosis with increase in neutrophils. Chest x-ray revealed pulmonary tuberculosis. The patient was given quadruple anti-Koch’s medication (pyrazinamide, rifampi- cin, ethambutol, isoniazid), prednisone, oral erythromycin and topical clobetasol propionate. Complete remission was attained at 10 months and is sustained at the time of writing.
Conclusion:To establish a definitive diagnosis and appropriate management, BP requires clinical, histopathologic, and immuno- logical correlation. Childhood BP has good prognosis and rapid treatment response, with rare relapses. - Full text:07_NOV 2022_DAVID.pdf
