Effect of telmisartan on plasma levels of inflammatory cytokine in unstable angina patients complicated with diabetes mellitus and hypertensive after percutaneous coronary intervention
- VernacularTitle:伴糖尿病及高血压的不稳定型心绞痛患者介入治疗后替米沙坦对血浆炎症因子水平的影响
- Author:
Xiaoling PENG
;
Zepeng LIN
;
Qiang LIU
;
Zhonghong LI
;
Guanglin JIN
;
Zhiwei ZHANG
;
Naisheng CAI
- Publication Type:Journal Article
- Keywords:
coronary artery disease, telmisartan, peroxisome proliferator-activators receptor γ, diabetes mellitus, C-reactive protein (CRP), monocyte heemoattractant protein-1 (MCP-1)
- From:
Chinese Journal of Rehabilitation Theory and Practice
2005;11(6):429-430
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo observe the effect of telmisartan on plasma levels of inflammatory cytokine in coronary artery disease (CAD) patients complicated with diabetes mellitus and hypertension after percutaneous coronary intervention.MethodsFifty CAD patients who just had undertook angioplasty and implanted stents were randomly divided into two groups, the test group (telmisartan group, n=25) and control group (perindopril group, n=25). After treatment, patients were followed-up for 6 months; plasma samples were collected from each patient before and after percutaneous coronary intervention. Then plasma levels of C-reactive protein (CRP), monocyte chemoattractant protein-1 (MCP-1) were measured by enzyme-linked immunoassay. The changes of cholesterol, fasting plasma glucose (FPG), insulin and insulin resistance index (IRI) were observed.ResultsAt the end of 6 months, plasma levels of CRP and MCP-1 of patients in the test group significantly declined (P<0.01), and showing a inversely correlation with FPG (P<0.01), and FPG, insulin and IRI also declined. In the control group, only CRP and MCP-1 declined (P<0.05). Meanwhile, the frequency of cardiovascular events in test group was significantly lower than that in the control group.ConclusionTelmisartan can decline plasma levels of CRP, MCP-1 and frequency of cardiovascular events as well as increasing insulin sensitivity and improving glucose metabolism to unstable angina patients.
