Study of mechanism on endothelial dysfunction of spontaneous hypertensive rats
- VernacularTitle:自发性高血压大鼠血管内皮功能不全发生机理实验研究
- Author:
Liufa DUAN
;
Qiufu ZHENG
;
Liping ZHANG
;
Qiang ZENG
;
Yingxian FAN
- Publication Type:Journal Article
- Keywords:
hypertension, endothelin (ET), nitric oxide
- From:
Chinese Journal of Rehabilitation Theory and Practice
2005;11(6):413-414
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the mechanism on endothelial dysfunction of spontaneous hypertensive rats (SHR).MethodsThe animals were divided into two groups: SHRs (n=8) and Wistar-Kyoto (WKY) rats (n=7) all aged 17 months. Blood pressure was measured by the tail-cuff method. NO3- concentration in serum was assayed by activated cadmium reduction method; endothelin (ET) and cGMP levels were assayed by RIA.ResultsCompared with WKY rats, blood NO3- concentration, ET level and vascular cGMP level of SHRs were all reduced significantly (P<0.01); vascular ET level was only uplifted slightly with no significant difference (P>0.05).ConclusionIt indicates that the vascular endothelial dysfunction in SHR is induced possibly by a diminished synthesis or release of NO, not by changes of ET level.
