Peripheral neuropathy and vasculopathy due to toxicity of acrylamide
- VernacularTitle:以轴索损害为主的围产期多发性周围神经病
- Author:
Yunying GAO
;
Li HONG
;
Hongyan BI
;
Yun YUAN
- Publication Type:Journal Article
- Keywords:
acrylamide, neurotoxicity, polyneuropathy, vasculopathy, pathology
- From:
Chinese Journal of Rehabilitation Theory and Practice
2005;11(5):398-399
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the clinical feature peripheral neuropathy and vasculopathy after acrylamide toxication. Methods2 young male patients with peripheral neuropathy who had exposed to acrylamide for job more than one year were reported.ResultsNeuroelectrophysiological examination showed marked abnormalities in both peripheral and central nerve conduction in both patients. Sural nerve biopsies revealed axonal degeneration, Wallerian degeneration and giant axon with accumulated neurofilaments. Additonally, vasculopathies including prominant thickness of arterial intesma and basal membrane of capillary as well as apoptosis of vascular pericyte, were evident. ConclusionAxonal degeneration and vascular involvement has been found in acrylamide toxication. Vascular impairment maybe plays an important role in the pathogenesis of neuropathy.
