A randomized, comparative study on the efficacy and safety of mangosteen 1% extract gel versus benzoyl peroxide 5% gel in the treatment of mild to moderate acne vulgaris
- Author:
Janice Natasha C. Ng
1
;
Maria Vinna N. Crisostomo
1
;
Margaret Stephanie L. Jimenez
1
;
Mary Jo Kristine S. Bunagan
1
Author Information
- Publication Type:Journal Article
- Keywords: Mangosteen extract
- MeSH: Acne Vulgaris; Benzoyl Peroxide
- From: Journal of the Philippine Dermatological Society 2021;30(2):15-23
- CountryPhilippines
- Language:English
-
Abstract:
Introduction:Acne vulgaris is a common dermatologic disorder caused by follicular epidermal hyperproliferation, excess se-
bum production, inflammation, and Cutibacterium acnes (C. acnes). The mangosteen fruit rind contains large amount of xantho-
nes, which has high antimicrobial activity against C. acnes.
Objectives:To compare the efficacy and safety of mangosteen 1% extract gel versus benzoyl peroxide (BPO) 5% gel in the treat- ment of mild to moderate acne vulgaris.
Methods:A total of 60 participants with mild to moderate acne or a rating of 2 or 3 in the Investigator’s Global Assessment (IGA) for acne were randomized to receive either mangosteen 1% extract gel or BPO 5% gel applied on the face twice daily over an 8-week period. Primary outcomes measured in the study were clinical remission graded as “clear” or “almost clear” (rating of 0 or 1) based on the IGA and any adverse reaction. - Full text:jpds 111.pdf
