Expression of caspase-3 in the rat brain following pentylenetetrazole-induced epilepsy
- VernacularTitle:Caspase-3在戊四氮急性致痫大鼠脑组织中的表达
- Author:
Xiao-ming GUO
;
Wei-wei WANG
;
Yin-hua WANG
- Publication Type:Journal Article
- Keywords:
epilepsy, caspase-3, cell apoptosis, pentylenetetrazole, rat
- From:
Chinese Journal of Rehabilitation Theory and Practice
2005;11(5):343-344
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the expression of caspase-3 in the brain of acutely pentylenetetrazole(PTZ)-kindled rats.MethodsThe caspase-3 positive cells were revealed using immunohistochemical SP method. CMIAS image analysis system was used to analyse the expression of caspase-3 hemi-quantitatively. ResultsFollowing PTZ induced epilepsy, the expression of caspase-3 increased both in the hippocampus and in the cortex, and that was more remarkable in the hippocampus than in the cortex.ConclusionCaspase-3 may be activated during neuronal apoptosis after epilepsy. Hippocampus is more sensitive to the neuronal damage due to epilepsy than the cortex is.
