Study of the relationship between gene polymorphism of vitamin D receptor, calcitonin receptor and bone mineral density of the Han nationality woman in Hebei
- VernacularTitle:VDR和CTR基因多态性与河北汉族妇女骨密度关系研究
- Author:
Minghui XU
;
Hedi LIU
;
Xiaoxu TONG
- Publication Type:Journal Article
- Keywords:
vitamin D receptor gene polymorphism, calcitonin receptor gene polymorphism, bone mineral density (BMD)
- From:
Chinese Journal of Rehabilitation Theory and Practice
2005;11(4):247-249
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo study the relationship between vitamin D receptor (VDR) gene polymorphism and calcitonin receptor (CTR) gene polymorphism, and bone mineral density (BMD) of the Han nationality woman in Hebei, explore the pathogenesis of osteoporosis (OP) at the gene level.MethodsPolymorphisms of VDR gene and CTR gene were analyzed by restriction fragment length polymorphisms (RFLPs) in 60 Han nationality women in Hebei.ResultsBb genetype of VDR had lower BMD values at all sites which were measured compared with bb genetype (P<0.05); CC genetype of CTR had tendency for lower BMD values at the L1～L4 compared with CT genetype (0.05
