The Relationship between Renal Function and Bone Marrow Density in Healthy Korean Women.
- Author:
Byung Kyu PARK
1
;
Ka Yeong YUN
;
Seung Chul KIM
;
Jong Kil JOO
;
Kyu Sup LEE
;
Ook Hwan CHOI
Author Information
- Publication Type:Original Article
- Keywords: Bone density; Creatinine; Cystatin C; Osteoporosis
- MeSH: Blood Urea Nitrogen; Body Mass Index; Bone Density; Bone Marrow*; Busan; Creatinine; Cross-Sectional Studies; Cystatin C; Female; Femur; Glomerular Filtration Rate; Health Promotion; Humans; Logistic Models; Menopause; Osteoporosis
- From:Journal of Menopausal Medicine 2017;23(2):96-101
- CountryRepublic of Korea
- Language:English
- Abstract: OBJECTIVES: The relationship between renal function and bone mineral density (BMD) is controversial. We evaluated the relationship between markers of renal function and BMD in healthy Korean women. METHODS: A total of 1,093 women who visited the health promotion center at Pusan National University hospital were included in the cross-sectional study. We divided the study population into two groups by BMD: osteopenia-osteoporosis and normal in the lumbar and femur regions, respectively. We compared the relationship between renal function and BMD using a logistic regression model and used SAS 9.3 (SAS Institute, Inc., Cary, NC, USA) for all statistical analysis. RESULTS: Blood urea nitrogen (BUN), creatinine, and cystatin C (Cys-C) were correlated with BMD in both the normal and osteopenia-osteoporosis groups, and in logistic regression analysis, BUN and Cys-C were correlated with lumbar and femur BMD. However, after we adjusted for age, menopause, and body mass index, only creatinine showed a negative correlation with lumbar BMD, and estimated glomerular filtration rate (eGFR) was related positively with femur BMD. CONCLUSIONS: Serum creatinine could be a marker for lumbar BMD and eGFR for femur BMD in Korean women without overt nephropathy.
