Experimental study of the compositive applying of nourishing Piyin Remedy and bovine brain extract on spinal cord injury of rats
- VernacularTitle:滋补脾阴方药联合牛脑提取液治疗大鼠脊髓损伤实验研究
- Author:
Hongfei WANG
;
Lingjie FU
;
Libin ZHAN
;
Lianjie ZHENG
;
Shuqin ZHANG
;
Yongjie LIU
;
Yanying MIAO
- Publication Type:Journal Article
- Keywords:
spinal cord injury (SCI), nourishing Piyin Remedy, bovine brain extract, rat
- From:
Chinese Journal of Rehabilitation Theory and Practice
2005;11(2):96-98
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo study the effect and mechanisms of nourishing Piyin Remedy (nPR) and bovine brain extract (bBE) on experimental spinal cord injury (SCI) of rat.Methods80 healthy SD rats were divided into 5 equal groups randomly: bBE group supplied through subarachnoid cavity, normal saline (NS) group supplied through subarachnoid cavity, nPR group, NS orally taken group, combined group. Animal models were made by Allen's equipment on T8～T9 segment. The spinal nerve function, somatosensory evoked potentials (SEP), retrograde and label technique of horseradish peroxidase, gross observation, histological and morphometric analysis were taken as the observed indices.ResultsThe values of observed indices of bBE group and nPR group improved evidently compared with their own control groups; that of combined group was prior to sole administration.ConclusionnPR can hold back the secondary SCI and accelerate the recovery of spinal nerve function; bBE can stimulate the improvement of injuried nerve fibers; the joint of nPR and bBE can make a synergic effect.
