Relationship of the change of calcitonin gene-related peptide and degeneration of the motor endplate after spinal cord injury in the rat
- VernacularTitle:大鼠完全性脊髓损伤后降钙素基因相关肽与运动终板的关系
- Author:
Qingmin ZHANG
;
Hua GUAN
;
Yi HONG
- Publication Type:Journal Article
- Keywords:
spinal cord injury (SCI), motor endplate (MEP), calcitonin gene reated peptide (CGRP), aetylcholinesterase (AChE), rat
- From:
Chinese Journal of Rehabilitation Theory and Practice
2005;11(2):89-90
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo observe changes of calcitonin gene related peptide (CGRP) and aetylcholinesterase (AChE) in motor endplate (MEP) after complete spinal cord injury (SCI) in the rat.MethodsSCI model of Wistar rats were established by transecting T10 spinal cord completely. The venters of the tibial anterior muscle were taken at 1, 2, 4 and 8 weeks postoperatively to carry out the experiment.The changes of CGRP and AChE in the MEP were investigated with immunohistochemical test.ResultsAfter complete SCI, the quantity and distribution of CGRP decreased in MEP of 1-week sample, and the changes of AChE were observed until 4-week sample, and although the staining was light and sparse, CGRP and AChE existed in MEP during 2 months postoperatively.ConclusionThere is degeneration of MEP in skeletal muscle after upper motor neuron injury; CGRP and AChE are related to the degeneration of MEP; CGRP test can show the changes of MEP earlier.
