Significance of detection of Tau protein and β amyloid protein levels in cerebrospinal fluid in patients with mild cognitive impairment
- VernacularTitle:轻度认知障碍患者脑脊液Tau蛋白及β淀粉样蛋白水平检测的意义
- Author:
Wei LI
;
Shenggang SUN
;
Etang DONG
;
Xingao WANG
;
Lidong JIAO
;
Chunyang LI
;
Hai PENG
- Publication Type:Journal Article
- Keywords:
mild cognitive impairment, Alzheimer disease, Tau protein, β amyloid protein
- From:
Chinese Journal of Rehabilitation Theory and Practice
2005;11(1):55-56
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo study the levels of Tau protein and β amyloid protein(Aβ) in cerebrospinal fluid(CSF) in patients with mild cognitive impairment(MCI) and their significance of diagnosis. MethodsSensitive enzyme linked immunosorbent assay were performed to detect the CSF levels of Tau protein and Aβ in 32 patients with MCI and 15 healthy controls. ResultsSignificant elevation of the level of Tau protein and decrease of the level of the Aβ were observed in patients with MCI compared with healthy controls.ConclusionThe assays of the CSF Tau and Aβprotein levels can provide valuable biological marker for the diagnoses and treatment of MCI.
