Relationship between the homocysteine level and stroke
- VernacularTitle:脑卒中与血同型半胱氨酸水平的关系
- Author:
Jiong ZHOU
;
Song-zhao ZHANG
;
Yun ZHANG
;
Zhong CHEN
;
Meiping DING
- Publication Type:Journal Article
- Keywords:
homocysteine(Hcy), cerebral infarction(CI), cerebral haemorrhage(CH), clinical neurological disfunction scale(CNDS), hematom volume(HV)
- From:
Chinese Journal of Rehabilitation Theory and Practice
2004;10(3):183-184
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo study the relationship between the homocysteine (Hcy) level and stroke. Methods57 cases, including cerebral haemorrhage (CH, 21 cases) and cerebral infarction (CI, 36 cases) , and 28 healthy cases as control group were selected to measure their level of Hcy, VitB12 , folic acid and creatinine(Cr). At the same time, the clinical neurological disfunction scale(CNDS) of all patients was evaluated and the hematom volume (HV) of the CH group was assayed. ResultsThe Hcy level of both CI and CH group was significantly higher than that of the control group(P<0.05 or P<0.01). No significant difference was found between CI and CH group on Hcy level. The Hcy level showed a very strong or strong reverse association with folic acid level in the CI and CH group (r=-0.442,P=0.007 or r=-0.531,P=0.013), but no significant correlation with VitB12 level. No correlation was found between Hcy level and CNDS in both the CI and CH group, either no correlation between Hcy level and HV in the CH group. ConclusionThere is a close relationship between hyperhomocysteine and stroke. Hcy level is reversely associated with folic acid level but not correlated with VitB12 level.
