Association between angiotensin converting enzyme gene polymorphism and cerebral infarction
- VernacularTitle:血管紧张素Ⅰ转换酶基因多态性与脑梗死的相关性研究
- Author:
Yu FU
;
Yin-hua WANG
;
Ru-ping XIE
;
Dafang CHEN
;
Yan ZHANG
;
Dongsheng FAN
;
Xiping XU
- Publication Type:Journal Article
- Keywords:
gene, angiotensin converting enzyme (ACE), cerebral infarction, risk factors
- From:
Chinese Journal of Rehabilitation Theory and Practice
2004;10(3):158-160
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo explore the association between angiotensin converting enzyme (ACE) gene insertion/deletion(I/D) polymorphism and cerebral infarction among Chinese people. MethodsThe ACE gene polymorphism was determined by PCR-RFLP in 242 patients with cerebral infarction and 283 controls. Multiple logistic regression was performed to explore the risk factors for cerebral infarction. ResultsAfter adjusting age, gender, alcohol drinking, smoking, education,history of diabetes mellitus and the primary hypertension, there was no significant association between ACE I/D polymorphism and cerebral infarction, either was hypertension and diabetes mellitus. The primary hypertension significanlly increased risk of cerebral infarction (OR=7.28,P =0.000). Both ACE ID/DD genotype and the primary hypertension showed a significant gene-environment interaction(r=1.62,OR=7.29), something as super multiplicative type 2 interaction. ConclusionAlthough ACE gene polymorphism is not risk factors of cerebral infarction, but ID/DD genotype had shown significant gene-environment interaction with primary hypertension in occurrence of cerebral infarcion.
