Histological observation on repair of bone mesenchymal stem cell in rabbit osteonecrosis of the femoral head defect model
- VernacularTitle:骨髓间充质干细胞对股骨头坏死缺损模型修复的组织学观察
- Author:
Wei SUN
;
Zirong LI
;
Zhencai SHI
;
Nianfei ZHANG
;
Yan LI
;
Fuzhai CUI
;
Lan ZHANG
;
Zhe CAI
- Publication Type:Journal Article
- Keywords:
osteonecrosis of the femoral head, bone defect, bone mesenchymal stem cell, rabbit
- From:
Chinese Journal of Rehabilitation Theory and Practice
2005;11(1):4-6
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo evaluate the effectiveness of mesenchymal stem cell (MSC) in osteonecrosis of the femoral head defect(ONFH) repair. MethodsAniaml model of ONFH defect were established with rabbits, which were divided into 3 groups,group A did not infill anything as control, nano Hydroxyapatite/collagen(nHAC) as group B,nHAC+MSC as group C.Histology change were investigated 4,8,12 weeks after operation respectively.Results groups B and C were different with group A. The difference between groups A and C was more significant. ConclusionMesenchymal stem cell has a strong activity of osteoconduction,it has a value in repairing the bone defect of ONFH and the treatment of ONFH.
