Effect of High-dose Methylprenisolone Pulse Treatment on Peritumor Edema Induced by Supratentorial Brain Tumors
- VernacularTitle:甲基强的松龙冲击治疗颅内幕上肿瘤脑水肿疗效观察
- Author:
Wei ZHANG
;
Yu WANG
;
Wei QI
;
Maozhi ZHANG
- Publication Type:Journal Article
- Keywords:
methylprednisolone, pulse treatment, peritumoral brain edema, edema index
- From:
Chinese Journal of Rehabilitation Theory and Practice
2007;13(12):1171-1173
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the clinical efficacy and adverse reactions of high-dose methylprednisolone pulse treatment on peritumoral edema induced by supratentorial brain tumors.Methods Thirty-five patients with supratentorial brain tumors and peritumoral edema were treated with methylprednisolone pulse therapy before surgery and the edema index of every patient was calculated by MRI examinations before and after methylprednisolone treatment.Results After methylprednisolone pulse therapy, the edema indexes of the light, medium and severe edema patients reduced by 1.79%, 8.81% and 12.02% respectively. The edema indexes of the medium and serious patients were significantly lower than that before treatment ( P<0.01). But the edema index of the light edema patients was not significantly different with that before treatment ( P>0.05).Conclusion High-dose methylprednisolone pulse therapy has an obvious effect on medium and serious peritumoral edema induced by supratentorial brain tumors and has no serious adverse reactions.
