Research progress in pharmacokinetics/pharmacodynamics and drug use of meropenem in special population
- VernacularTitle:美罗培南药动学/药效学及特殊人群用药的研究进展
- Author:
Hongyan XU
1
,
2
;
Jian HUANG
1
,
2
;
Along WU
1
;
Bingfa XU
1
Author Information
1. Dept. of Pharmacy，the Third Affiliated Hospital of Anhui Medical University，Hefei 230061，China
2. College of Pharmacy，Anhui Medical University，Hefei 230061，China
- Publication Type:Journal Article
- Keywords:
meropenem;
pharmacodynamics;
pharmacokinetics;
drug interaction;
therapeutic drug monitoring
- From:
China Pharmacy
2023;34(13):1661-1664
- CountryChina
- Language:Chinese
-
Abstract:
Meropenem is the first choice for the treatment of multi-drug-resistant bacterial infections， which has been widely used in clinical practice. However， the physiological and pathological characteristics of special populations have a significant impact on the pharmacokinetics/pharmacodynamics （PK/PD） parameters of meropenem， so it is necessary to develop individualized drug administration plan according to the characteristics of patients in clinical application. Therefore， this paper summarizes PK/PD characteristics and application of meropenem in special population， and recommends the dosage of meropenem as follows： 10-40 mg/kg， q8 h for children； 1 g， q8-12 h for elderly patients； 0.75 g， q8 h for the patients with renal insufficiency who received continuous veno-venous hemofiltration and continuous veno-venous hemodialysis； 1 g， q8 h prolonged infusion until 3 hours or 2 g， q8 h for patients with hyperrenal function； 1 g， q8 h after 2 g loading dose for patients with cirrhosis.
