Meta-analysis of the safety of polysaccharide iron complex versus ferrous sulfate in the treatment of anemia during pregnancy
- VernacularTitle:多糖铁对比硫酸亚铁用于妊娠期贫血安全性的Meta分析
- Author:
Guangyan WANG
1
;
Lu LIU
1
;
Qiaoli WANG
2
;
Meixing YAN
1
;
Chang LIU
1
Author Information
1. Dept. of Pharmacy，Women and Children’s Hospital of Qingdao University，Shandong Qingdao 266034，China
2. Dept. of Pharmacy，Qingdao Central Medical Group，Shandong Qingdao 266042，China
- Publication Type:Journal Article
- Keywords:
anemia during pregnancy;
polysaccharide iron
- From:
China Pharmacy
2023;34(13):1627-1631
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To compare the safety of polysaccharide iron complex and ferrous sulfate in the treatment of anemia during pregnancy. METHODS Retrieved from Cochrane Library， PubMed， Embase， SinoMed， CNKI， VIP and Wanfang database， randomized controlled trials （RCTs） about polysaccharide iron complex （trial group） versus ferrous sulfate （control group） in the treatment of anemia during pregnancy were collected from the inception to May 20th， 2022. After literature screening， data extraction and quality evaluation， meta-analysis， sensitivity analysis and publication bias analysis were conducted with RevMan 5.3 software. RESULTS A total of 13 RCTs were included， with a total of 1 318 patients. Results of meta-analysis showed that the total incidence of adverse drug reactions （ADR） [RR＝0.11， 95%CI （0.06， 0.18）， P＜0 000 01]， gastrointestinal adverse reactions [RR＝0.08， 95%CI （0.05， 0.12）， P＜0.000 01]， anorexia and nausea [RR＝0.21， 95%CI （0.09， 0.54）， P＝ 0.001]， abdominal pain [RR＝0.18， 95%CI （0.04， 0.78）， P＝0.02]， diarrhea [RR＝0.18， 95%CI （0.04， 0.79）， P＝0.02]， vomiting [RR＝0.24， 95%CI （0.06， 0.89）， P＝0.03] and gingival melanosis [RR＝0.09， 95%CI （0.03， 0.28）， P＜0.000 1] in the trial group were all significantly lower than the control group. The results of sensitivity analysis showed that the conclusions obtained in this study were relatively robust. The results of publication bias analysis indicated that there was a high possibility of publication bias in this study. CONCLUSIONS The polysaccharide iron complex is safer than ferrous sulfate for treatment of anemia during pregnancy.
