Guideline for the prevention and control of occupational exposure risks to cytotoxic drugs in medical institutions
- VernacularTitle:医疗机构细胞毒性药物职业暴露风险防控指南
- Author:
Linke ZOU
1
;
Junfeng YAN
1
;
Hui LIU
2
;
Ziyan LYU
1
Author Information
1. Personalized Drug Therapy Key Laboratory of Sichuan Provincial，Dept. of Pharmacy，Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital/ Affiliated Hospital of UESTC，Chengdu 610072，China
2. School of Medicine，University of Electronic Science and Technology of China，Chengdu 610072，China
- Publication Type:Journal Article
- Keywords:
cytotoxic drug;
occupational exposure;
risk prevention and control;
guideline;
medical institutions
- From:
China Pharmacy
2023;34(13):1537-1546
- CountryChina
- Language:Chinese
-
Abstract:
To provide prevention and control strategies of occupational exposure risks to cytotoxic drug in medical institutions， improve the awareness of protection among medical staff，and reduce potential occupational exposure risks，the Guidelines for the Prevention and Control of Occupational Exposure Risk to Cytotoxic Drugs in Medical Institutions is developed. Based on the World Health Organization Guidelines Development Manual，the exposure risk issues of the cytotoxic drug collected from the time that it entered the hospital to the several stages after delivery to hospital，such as transportation，receipt，storage，unpacking，dispensing，use of finished products，and waste disposal. Delphi method is used to construct identification of clinical issues，and evidence-based research method is used to develop relevant evidence. Quality evaluation is conducted by using the recommended GRADE method. The consensus is reached on the recommendation opinions and evidence levels through expert consensus method. By combining engineering controls，administrative controls and personal protective equipment at different levels，a graded control approach is established. A total of 37 clinical issues are identified，resulting in 36 recommendations. This guideline provides reference and supplementation for the formulation of cytotoxic drug prevention and control measures in medical institutions.
