Effects of XinShu Parenteral Solution on the function of platelet,the changes of fibrinolysis system after intima denudation of rabbits
- VernacularTitle:欣舒注射液对兔血管内膜剥脱术后血小板活化及纤溶活性的影响
- Author:
Cheng-long WANG
;
Ji-wu YANG
;
Zhong-xiang LIN
- Publication Type:Journal Article
- Keywords:
XinShu parenteral solution(XSPS), intima denudation, α granule membrane protein of platelets(GMP-140), tissue-type plasminogen activator(t-PA), plasminogen activator inhibitor-type Ⅰ(PAI-1)
- From:
Chinese Journal of Rehabilitation Theory and Practice
2004;10(1):34-35
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo observe the effects of XinShu parenteral solution (XSPS) on the activation of platelet, the activity of fibrinolysis system after intima denudation of rabbits.Methods20 male Japanese white rabbits (2.5±0.5)kg were randomly divided into the control group and XSPS group .The celiac arterial endothelium of all rabbits were denuded with balloon. Before the operation and 3d, 7d, after balloon denudation, vein blood samples were obtained from each group rabbits for measurement of α granule membrane protein of platelets(GMP-140), tissue-type plasminogen activator(t-PA) and plasminogen activator inhibitor-type Ⅰ(PAI-1).ResultsPlasma GMP-140 and PAI-1 activity obviously elevated after balloon injury, and there was a little elevation in plasma t-PA activity in control group. Activity of plasma GMP-140 in XSPS group remained bottom level after balloon injury, and there was a significant increase in plasma t-PA activity and a marked reduce in PAI-1 activity in XSPS group. There was a notable difference between group B and group C (P<0.05). ConclusionXSPS obviously inhibits platelet activation, and improves fibrinolysis activity after balloon injury.
