Biocompatibility of Injured Nerve Regenerated Materid following experimental traumatic brain injury in rats cortex
- VernacularTitle:壳聚糖生物活性载体植入大鼠脑皮质后的生物相容性研究
- Author:
Er-jing GAO
;
Bing-fang LIU
;
Qiang LU
;
Yujun LIU
;
Qing CAI
;
Xiaoguang LI
- Publication Type:Journal Article
- Keywords:
biocompatibility, tissue engineering, brain injury, chitosan, rats
- From:
Chinese Journal of Rehabilitation Theory and Practice
2004;10(1):28-30
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo evaluate the biocompatibility of a kind of scaffolding material,Injured Nerve Regenerated Materid(INRM), which play the roles of regeneration of nerve after traumatic brain injury.MethodsINRM scaffolding material were transplanted into cortex of rats after traumatic injury.The brain coronal sections were stained for Nissel, astrocyte and microglia at 1 week, 1 month, and 2 months after injury.ResultsThe presence of INRM did not alter patterns of astrocyte compared with the control group (detected with antibodies against GFAP) at any time point; but decreased the expression of microglias (detected with antibodies against OX42) compared with the control group.ConclusionThe biomaterial INRM is well suited as a biocompatible scaffold material for the repair of brain injury in the brain.
