Effect and mechanism of vagus nerve stimulation on seizure in animal with epilepsy
- VernacularTitle:迷走神经刺激对致痫动物的抗痫作用及其机理研究
- Author:
Lan-feng ZHAO
;
Jing-jin LI
;
Yang-yuan AN
;
Yizhen WANG
- Publication Type:Journal Article
- Keywords:
epilepsy, seizure, vagus nerve, stimulation
- From:
Chinese Journal of Rehabilitation Theory and Practice
2004;10(1):25-27
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo study the effect and mechanism of vagus nerve stimulation(VNS) on seizure in animal with epilepsy.MethodsSeizures of 34 rats and 8 rabbits were induced by Penicillin, Kainic acid(KA) and Strychnice respectively. Electrocorticographic(ECoG), electrical activition of hippocampal neurons and behaviour were observed to evidence the effects of left intermittent VNS .ResultsVNS could suppress seizures in animal models with epilepsy. There were significant changes in epileptiform ECoG, discharges of hippcampal neuron and behaviour. ConclusionSomatic seizure can be effectively inhibited by visceral afferent inputs through integration in cortical and hippocampal parts.
