Research on repairing facial nerve injury of rabbits by neural stem cells and autologous fasia
- VernacularTitle:神经干细胞与自体筋膜联合修复家兔面神经损伤
- Author:
Chang-xiang YAN
;
Yi-hua AN
;
Jun-hua LI
;
Shuling LIU
;
Hong WAN
;
Chunjiang YU
;
Zhongcheng WANG
- Publication Type:Journal Article
- Keywords:
neural stem cells, autologous fasia, facial nerve injury, repair
- From:
Chinese Journal of Rehabilitation Theory and Practice
2004;10(1):21-22
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo observe the effect on repairing facial nerve injury of rabbits by neural stem cells and autologous fasia. Methods22 rabbits with transected facial nerve were divided into 2 groups randomly, control group (8 rabbits,15 sides totally), which transected facial nerve were wrapped by autologous fasia, and treament group (14 rabbits, 20 sides totally), which were wrapped by neural stem cells and autologous fasia. Six weeks after transplantation, neuro-electrophysiological test, immunohistochemical examination were done. The number and thickness of myelin in the re-connected area of transected facial nerve were observed. ResultsThe transplanted animals recovered much better than that in control group (P<0.05). Immunohistochemical examination showed a great deal of BrdU positive cells around the re-connected area of transected facial nerve. Immunohistochemical staining also found plenty of regenerative myelins in this area in the treatment group. While in control group, there were no BrdU positive cells and only a few of regenerative myelins in the same area. ConclusionTransplantation of neural stem cells combined with autologous fasia might become the new method to treat facial nerve injury.
