Mechanism of Nogo and Its Receptors during Repairing of Spinal Cord Injury (review)
- VernacularTitle:Nogo及其受体在脊髓损伤修复中的作用机制
- Author:
Yongtang WANG
;
Xiumin LU
;
Lin ZENG
;
Jie GAO
;
Yamin WU
- Publication Type:Journal Article
- Keywords:
Nogo-A, Nogo receptor complex, axon regeneration, spinal cord injury, review
- From:
Chinese Journal of Rehabilitation Theory and Practice
2007;13(11):1008-1010
- CountryChina
- Language:Chinese
-
Abstract:
Myelin of the adult mammalian central nervous system(CNS)has been attributed to affect nerve structural plasticity and suppress regeneration of nerve fibers.Nogo-A is possibly the best characterized of a variety of neurite growth inhibitors in CNS myelin.Neutralizing its activity results in improved axon regrowth and functional recovery in experimental spinal cord injury(SCI)models of animals.Nogo-A and its receptors,especially Nogo-66 receptor(NgR),p75 neurotrophin receptor(p75NTR),and LINGO-1 increasingly become the hot spot in the study of SCI repair,and have become the major targets for therapeutic intervention to promote axon regeneration after SCI.Inhibition of Nogo-A and its receptors NgR/p75NTR/LINGO-1 may be promote the regeneration of axon and maximize functional recovery after SCI.
