Optimal Dose of Botulinum Toxin A to Release Spasticity of Triceps Surae in Children with Cerebral Palsy
- VernacularTitle:A型肉毒毒素缓解脑瘫儿童小腿三头肌痉挛最佳剂量研究
- Author:
Jian-jun LIU
;
Shu-rong JI
;
Ying-yuan HU
;
Weihong WU
;
Yanchun LI
;
Huabao LU
;
Yan ZHANG
- Publication Type:Journal Article
- Keywords:
cerebral palsy, spasm, botulinum toxin A(BTX-A), nerve block, dose
- From:
Chinese Journal of Rehabilitation Theory and Practice
2008;14(12):1173-1176
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine the coefficient in the formula of the optimal dose of botulinum toxin A(BTX-A) to treat spastic cerebral palsy(CP).Methods58 CP children(male 38,female 20,mean age 59.3±24.6 months,range 27 to 144 months) were divided into A,B,C,D and E five groups according to used coefficient and treated by BTX-A with different doses to release the spasticity.ResultsAccording to the improvement of motor function,the BTX-A dose of the group D was optimal.According to the effective endurance,the BTX-A dose of the group C was optimal.The optimal coefficient was 1.8.ConclusionThe formula of the optimal BTX-A dose injected in triceps surae is dose =(1+1.8×MAS score)×body weight.
