PPAR-γ:A New Target of Treatment for Inflammatory Reaction after Cerebral Ischemic by Acupuncture(review)
- VernacularTitle:针灸治疗脑缺血炎症反应的新靶点—PPAR-γ
- Author:
Zhe LIU
;
Pei LIU
;
Yong-wang ZHU
;
Jianqiao FANG
- Publication Type:Journal Article
- Keywords:
cerebral ischemia, inflammatory reaction, peroxisome proliferator-activated receptors-γ(PPAR-γ), acupuncture, review
- From:
Chinese Journal of Rehabilitation Theory and Practice
2008;14(12):1143-1145
- CountryChina
- Language:Chinese
-
Abstract:
The inflammatory reaction after acute cerebral infarction can aggravate the cerebral ischemic reperfusion injury.Activation of peroxisome proliferator-activated receptors-γ(PPAR-γ) has neuroprotective effects by which induces anti-inflammatory actions in cerebral ischaemia,thus as a potential novel pharmacological target for ischemic stroke was regarded.Acupuncture can improve cerebral ischemia injury by inhibiting synthesis of inflammatory cytokines,downregulating expressions of inflammatory mediators and adhesion molecule,suppressing the functions of inflammatory cells.Therefore,it will be a promising orientation to sift the effective acupuncture for that can stimulate the activation of PPAR-γ,and the research of mechanism of acupuncture on anti-inflammatory reaction after cerebral ischemic by activating PPAR-γ dependent pathways.
